Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians
Authors' conclusion
Our findings support a role for NFIA-AS2 in regulating pathways that impact BMI.
Study context
- Population
- Southwestern American Indians, population-based sample; meta-analysed with GIANT body mass index (BMI) dataAmerican Indians · meta-analysed with GIANT BMI data 240,608
- Participants
- 5,870 indians
- Outcome
- Association of genetic variants with BMI
Methodological detailspopulation-based, meta-analysis with GIANT, in-silico and in-vitro functional studies
- Population-based
- Meta-analysis with GIANT
- In-silico and in-vitro functional studies
Pooled result
As reported in the abstract
BMI association of rs1777538 (NFIA-AS2 lead variant)
- C allele frequency in American Indians
- 0.16
- C allele frequency in GIANT
- 0.04
- Meta-analysis P
- P = 5.0 × 10-7
- BMI change per copy of C allele in American Indians
- 1 kg/m² decrease
Further pooled results
NFIA-AS2 characterization
- Nuclear localized lncRNA expressed in tissues pertinent to human obesity
RNA degradation of NFIA-AS2 transcripts in human brown preadipocytes
h
- C allele transcripts had increased RNA degradation vs T allele; half-life C allele
- 9
- Half-life T allele
- 13
Allelic difference in regulation of nearby gene expression in mature brown adipocytes
- Strongest allelic difference, L1TD1
- P = 0.007
Original publication
Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians. Int J Obes (Lond). Published 17 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →