Predictability of genetic risk score for insulin resistance is influenced by both BMI and race
Authors' conclusion
These results highlight the heterogeneity of IR and support the hypothesis that the relationship between genetic predisposition for IR and obesity is race- and tissue-specific.
Study context
- Population
- African American (AA) and European American (EA) adults without diabetes, classified into high or low BMI using the sample median (25.9 kg/m²) as cut point
- Participants
- 53 vs 54
- Exposure
- High vs low BMI status in associations of genetic risk score (GRS) for insulin resistance (IR) with insulin sensitivity, by race
- AAn = 53
- EAn = 54
- Outcome
- Interactions between BMI status and GRS (52 variants) on insulin sensitivity: clamp (skeletal muscle), HOMA-IR (hepatic) and Matsuda index (whole-body)
Methodological detailsstratified by race
- Stratified by race
Main finding
As reported in the abstract
GRS–insulin sensitivity associations by BMI status
- EA: associations of GRS with homeostasis model assessment of insulin resistance (HOMA-IR) and Matsuda index differed by BMI status; GRS associated with IR in high-BMI group only
- AA: clamp associations differed by BMI status; association observed only in low-BMI group
Observational data: associations, not effects.
Original publication
Predictability of genetic risk score for insulin resistance is influenced by both BMI and race. Obesity (Silver Spring). Published 24 February 2025. doi:10.
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