Impact of Genetic Predisposition to Obesity on Long‐Term Maintenance of Modest Weight Loss in Postmenopausal Women
Authors' conclusion
A high PRSBMI was associated with faster weight regain following modest weight loss in European American women. While further validation is required in a diverse population, these results suggest the potential for genetics to inform targeted strategies for sustaining long-term weight management.
Study context
- Population
- Postmenopausal women from the Women's Health Initiative Dietary Modification Trial (6132 European American; 3749 African American)
- Participants
- 9,897 women
- Comparison
- High vs average polygenic risk score of BMI
- Primary endpoint
- Modification of weight trajectories by PRSBMI (PRSBMI × randomization × time interaction)
- Follow-up
- 7 years
Methodological detailspolygenic risk score, weighted GEE, 7-year longitudinal weight change
- Polygenic risk score
- Weighted GEE
- 7-year longitudinal weight change
Primary result
As reported in the abstract
PRSBMI × randomization × time interaction on weight change
- European Americans, 95th percentile: interaction approached significance
- p = 0.052
- European Americans, 85th percentile: interaction approached significance
- p = 0.07
Further findings
Weight regain per year in European Americans who lost ≥ 5% of initial weight by year 1 (20%; n = 1273) · nearly twice as much regain with ≥ 95th percentile
P = 0.0016
Original publication
Impact of Genetic Predisposition to Obesity on Long‐Term Maintenance of Modest Weight Loss in Postmenopausal Women. Obesity (Silver Spring). Published 6 March 2026. doi:10.
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