Joint The Obesity Society (TOS) / Obesity Medicine Association (OMA) / Obesity Action Coalition (OAC) Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Approach
Methodological detailsGRADE approach, multidisciplinary panel including patient representatives, systematic evidence synthesis via Epistemonikos, consensus workshops
- GRADE approach
- Multidisciplinary panel including patient representatives
- Systematic evidence synthesis via Epistemonikos
- Consensus workshops
Recommendations
As issued by the authors
- Strong; moderate-certainty evidence
Bupropion-naltrexone, semaglutide, tirzepatide and setmelanotide
- Conditional
Other agents and specific obesity complications (obstructive sleep apnea, HF with preserved ejection fraction, MASLD/MASH, osteoarthritis, MACE, T2D)
- Strong
Continuing obesity medications during weight maintenance
Original publication
Joint TOS / OMA / OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach. Obesity (Silver Spring). Published 5 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →