Establishing causal relationships between sleep and adiposity traits using Mendelian randomization
Authors' conclusion
The effects of insomnia on adiposity and of adiposity on daytime sleepiness suggest that poor sleep and weight gain may contribute to a feedback loop that could be detrimental to overall health.
Study context
- Population
- UK Biobank and 23andMe (sleep traits: chronotype N = 697,828; insomnia N = 1,331,010; sleep duration N = 446,118; napping N = 452,633; daytime sleepiness N = 452,071); Genetic Investigation of ANthropometric Traits (GIANT) and Early Growth Genetics (EGG) consortia (adult BMI, hip circumference (HC), waist circumference (WC), waist-hip ratio (WHR) N = 322,154; childhood BMI N = 35,668)
- Comparison
- Genetically predicted sleep traits vs adiposity traits, in both directions
- Outcome
- Causal effects between sleep and adiposity traits
Methodological detailsbidirectional
- Bidirectional
Main finding
As reported in the abstract
- Insomnia → WC, difference in means
- 0.39 SD (95% CI 0.13-0.64)
- Insomnia → BMI, difference in means
- 0.47 SD (95% CI 0.22-0.73)
- Insomnia → WHR, difference in means
- 0.34 SD (95% CI 0.16-0.52)
- Napping → mean WHR
- 0.23 SD (95% CI 0.08-0.39)
- Higher HC → odds of daytime sleepiness
- 0.02 SD (95% CI 0.01-0.04)
- Higher WC → odds of daytime sleepiness
- 0.04 SD (95% CI 0.01-0.06)
- Higher adult BMI → odds of daytime sleepiness
- 0.02 SD (95% CI 0.00-0.04)
- Higher childhood BMI → lower odds of napping
- −0.01 SD (95% CI 0.02-0.00)
Original publication
Establishing causal relationships between sleep and adiposity traits using Mendelian randomization. Obesity (Silver Spring). Published 15 February 2023. doi:10.
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