Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study
Authors' conclusion
Genetic causal modelling indicates negative effects of insulin resistance on childhood and adult adiposity, and negative effects of IGF-1 resistance on childhood adiposity. Our findings demonstrate the need to distinguish between bioaction and resistance when modelling variants associated with biomarker concentrations.
Study context
- Comparison
- Genetically predicted fasting insulin and IGF-1 vs childhood adiposity and adult body mass index (BMI)
- Outcome
- Relative childhood adiposity and adult BMI
Methodological detailstwo-sample, Steiger filtering, 'biological effect' filtering
- Two-sample
- Steiger filtering
- 'biological effect' filtering
Main finding
As reported in the abstract
Likely causal effects of fasting insulin and IGF-1 on relative childhood adiposity and adult BMI
- Fasting insulin-increasing alleles (35 variants, insulin resistance): lower relative childhood adiposity
- P = 3.8 × 10-3
- Fasting insulin-increasing alleles (35 variants, insulin resistance): lower adult BMI
- P = 1.4 × 10-5
- IGF-1-increasing alleles with taller childhood height (351 variants, greater IGF-1 bioaction): no association with relative childhood adiposity
- P = 0.077
- IGF-1-increasing alleles with taller childhood height (351 variants): no association with adult BMI
- P = 0.562
- IGF-1-increasing alleles with shorter childhood height (306 variants, IGF-1 resistance): lower relative childhood adiposity
- P = 6.7 × 10-3
Original publication
Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study. Int J Obes (Lond). Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →