Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study
Authors' conclusion
Childhood adiposity is a risk factor not only for adult-onset diabetes primarily characterised by obesity or insulin resistance, but also for subtypes primarily characterised by insulin deficiency or autoimmunity. These findings emphasise the importance of preventing childhood obesity.
Study context
- Population
- European GWAS of childhood adiposity, latent autoimmune diabetes in adults (LADA), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), MOD and mild age-related diabetes (MARD)
- Comparison
- Genetically predicted higher childhood adiposity and risk of adult-onset diabetes subtypes
- Outcome
- Adult-onset diabetes subtypes: LADA, SIDD, SIRD, MOD and MARD
Methodological detailstwo-sample Mendelian randomisation (MR) using European GWAS data
- Two-sample MR using European GWAS data
Main finding
As reported in the abstract
Genetically predicted effect of higher childhood adiposity on diabetes subtypes
- LADA: OR
- 1.62 (1.05, 2.52) (95% CI)
- SIDD: OR
- 2.11 (1.18, 3.80) (95% CI)
- SIRD: OR
- 2.76 (1.60, 4.75) (95% CI)
- MOD: OR
- 7.30 (4.17, 12.78) (95% CI)
- MARD: OR (95% CI), no effect
- 1.06 (0.70, 1.60)
Original publication
Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study. Diabetologia. Published 27 February 2023. doi:10.
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