Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study
Authors' conclusion
Fetal-determined but not maternal-determined lower BW were associated with increased risks of adulthood type 2 diabetes and its subtypes. Our results underscored the importance of early targeted management among people with a low BW in the prevention of type 2 diabetes.
Study context
- Population
- Not stated beyond genetic data for birth weight and T2D subtypes (mild age-related diabetes (MARD), MOD, severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD))
- Comparison
- Genetically determined lower birth weight (overall, fetal-determined, maternal-determined) and risk of T2D and its subtypes
- Outcome
- Risk of T2D and its subtypes: mild age-related diabetes (MARD), mild obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD)
Main finding
As reported in the abstract
Lower birth weight (overall) and risk of T2D and subtypes
- T2D, OR
- 1.86 (1.53, 2.26) (95% CI)
- MARD, OR
- 2.15 (1.43, 3.23) (95% CI)
- MOD, OR
- 1.75 (1.10, 2.77) (95% CI)
- SIDD, OR
- 1.86 (1.11, 3.10) (95% CI)
- SIRD, OR
- 1.66 (1.06, 2.60) (95% CI)
Further findings
Fetal-determined lower birth weight
- Lower birth weight (BW) remained associated with T2D and its subtypes, except for MOD
Maternal-determined lower birth weight (adverse intrauterine environment proxy)
- No evidence that it raised offspring risks of T2D
Original publication
Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study. J Clin Endocrinol Metab. Published 4 July 2024. doi:10.
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