Life‐course adiposity and severe liver disease: a Mendelian randomization analysis
Authors' conclusion
The current study provided genetic evidence on the associations between life-course adiposity and SLD.
Study context
- Population
- Genetic variants from genome-wide association studies; China Kadoorie Biobank
- Comparison
- Genetically predicted life-course adiposity and severe liver disease
- Outcome
- Severe liver disease (SLD; cirrhosis and liver cancer)
Methodological detailstwo-sample, meta-analysis of Mendelian randomization (MR) results, genetic risk score Cox regression in China Kadoorie Biobank
- Two-sample
- Meta-analysis of MR results
- Genetic risk score Cox regression in China Kadoorie Biobank
Pooled result
As reported in the abstract
SLD (meta-analyses of MR results)
Genetically predicted 1-SD increase in birth weight: OR (95% CI) for severe liver disease (SLD), marginal significance
0.81
0.65–1.00
Genetically predicted 1-SD higher childhood BMI: OR (95% CI) for SLD
1.27
1.05–1.55
Genetically predicted 1-SD higher adulthood BMI: OR (95% CI) for SLD
1.79
1.59–2.01
Further pooled results
Observational analyses (genetic risk scores, China Kadoorie Biobank)
- Genetic predispositions to childhood and adulthood adiposity were each associated with SLD
- U-shaped association between adulthood weight change and risk of SLD
Liver biomarkers
- Results of liver biomarkers mirrored those of SLD
Original publication
Life‐course adiposity and severe liver disease: a Mendelian randomization analysis. Obesity (Silver Spring). Published 23 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →