Birth weight, childhood obesity, adulthood obesity and body composition, and gastrointestinal diseases: a Mendelian randomization study
Authors' conclusion
This study suggests that greater adulthood adiposity, measured as either BMI, waist-hip ratio, or visceral adipose tissue, is causally associated with an increased risk of a broad range of gastrointestinal diseases in the European population.
Study context
- Population
- European ancestry; summary-level data from UK Biobank, FinnGen and large consortia
- Comparison
- Genetically predicted birth weight, childhood BMI, adulthood BMI, WHR and body composition vs risk of 24 gastrointestinal diseases
- Outcome
- Risk of 24 gastrointestinal diseases
Methodological detailsgenome-wide significance instruments (p < 5 × 10-8 ), summary-level data
- Genome-wide significance instruments (p < 5 × 10-8 )
- Summary-level data
Main finding
As reported in the abstract
Associations of genetically predicted exposures with gastrointestinal diseases
Higher adulthood BMI associated with gastrointestinal diseases (number)
19
Higher WHR associated with gastrointestinal diseases (number)
17
Greater visceral adiposity associated with increased risk of gastrointestinal diseases (number)
17
Original publication
Birth weight, childhood obesity, adulthood obesity and body composition, and gastrointestinal diseases: a Mendelian randomization study. Obesity (Silver Spring). Published 4 September 2023. doi:10.
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