Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases
Authors' conclusion
This study provides new evidence on the relationships between childhood obesity and adult cholelithiasis, highlighting the role of early intervention for obesity in childhood at key time points. MLXIPL gene expression was identified as a potential biological pathway, suggesting potential therapeutic targets and precise intervention strategies for childhood obesity and adult cholelithiasis.
Study context
- Population
- GWAS summary statistics of childhood age-specific body mass index (BMI) at 12 time points (birth to 8 years) and adult cholelithiasis from FinnGen; UK Biobank for sensitivity analyses
- Comparison
- Genetically predicted age-specific childhood BMI (birth to 8 years, 12 time points) and adult cholelithiasis
- Outcome
- Adult cholelithiasis
Methodological detailsLDSC genetic correlation, two-sample Mendelian randomization (MR), multivariable MR, SMR, transcriptome-wide association studies (TWAS), Bayesian colocalization, UK Biobank sensitivity analyses
- LDSC genetic correlation
- Two-sample MR
- Multivariable MR
- SMR
- TWAS
- Bayesian colocalization
- UK Biobank sensitivity analyses
Main finding
As reported in the abstract
- LDSC: significant genetic correlations between 11 age-specific childhood BMIs and adult cholelithiasis (except birth BMI)
- Two-sample MR and multivariable Mendelian randomization (MVMR): causal relationships between BMI at birth, 8 months, 1.5 years, 7 years and 8 years and adult cholelithiasis
- SMR, TWAS and colocalization: MLXIPL the strongest overlapping signal between age-specific BMI and adult cholelithiasis
Original publication
Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases. Int J Obes (Lond). Published 22 August 2025. doi:10.
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