Causal relationships between birth weight, childhood obesity and age at menarche: A two‐sample Mendelian randomization analysis
Authors' conclusion
Our MR study suggests the causal effect of lower birth weight and higher childhood BMI on the increased risk of earlier menarche. It may be the opportune time to carry out weight control intervention in prenatal and early childhood development periods to prevent early menarche onset, thus decreasing the future adverse consequences.
Study context
- Population
- GWAS summary statistics: birth weight, childhood body mass index (BMI), age at menarchebirth weight 143,677 · childhood BMI 39,620 · age at menarche 182,416
- Comparison
- Genetically predicted birth weight and childhood BMI vs age at menarche
- Outcome
- Age at menarche
Methodological detailsinverse variance weighted Mendelian randomization (MR), GWAS summary statistics, sensitivity analyses: maximum likelihood, weighted-median, MR-PRESSO
- Inverse variance weighted MR
- GWAS summary statistics
- Sensitivity analyses: maximum likelihood, weighted-median, MR-PRESSO
Main finding
As reported in the abstract
- Per 1-SD lower birth weight: 0.1479 years earlier menarche (β = .1479, 95% CI 0.0422-0.2535; p = 0.0061)
- Per 1-SD increase in childhood BMI: earlier menarche (β = −.3966, 95% CI −0.5294 to −0.2639; p = 4.73E-09)
- Inverse variance weighted MR
Original publication
Causal relationships between birth weight, childhood obesity and age at menarche: A two‐sample Mendelian randomization analysis. Clin Endocrinol (Oxf). Published 25 October 2022. doi:10.
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