Preschool age-specific obesity and later-life kidney health: a Mendelian randomization and colocalization study
Authors' conclusion
Our study supports the association between preschool obesity and kidney health, emphasizing the role of adult BMI in this relationship. These findings underscore the importance of interventions starting in early childhood and continuing through adulthood to reduce the long-term risk of obesity-related kidney damage.
Study context
- Population
- Largest available genome-wide association studies
- Comparison
- Genetically predicted preschool age-specific obesity and kidney health
- Outcome
- Kidney health and diseases: Blood urea nitrogen (BUN), eGFRcrea, eGFRcys, CKD, IgA nephropathy, diabetic nephropathy
Methodological detailstwo-sample mendelian randomization (MR), multivariable MR, stepwise MR, colocalization analysis
- Two-sample MR
- Multivariable MR
- Stepwise MR
- Colocalization analysis
Main finding
As reported in the abstract
Kidney health and disease
- Preschool obesity could be associated with kidney health and disease
- Direction of association between age-specific body mass index (BMI) and chronic kidney disease (CKD) switched: negative before 3 years old, positive after 3 years old
Further findings
Mediating pathways (multivariable Mendelian randomization (MVMR) and stepwise MR)
- Potential pathways linking preschool obesity to kidney health involve adult BMI, circulating HDL-C and circulating C-reactive protein
Colocalization
- Preschool-age BMI and kidney function could share causal variants: rs76111507, rs62107261, rs77165542 (chromosome 2) and rs571312 (chromosome 18)
Original publication
Preschool age-specific obesity and later-life kidney health: a Mendelian randomization and colocalization study. Int J Obes (Lond). Published 21 November 2024. doi:10.
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