Gestational diabetes & diabetes in pregnancy
Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study
Authors' conclusion
Our findings supported a deleterious causal effect of obesity on GDM risk, where lipid metabolism acted as potential drivers of the relationships between both general and central obesity and GDM.
Study context
- Population
- Summary-level data from the largest available genome-wide association studies of five obesity traits, five lipid traits and GDM
- Comparison
- Genetically predicted obesity traits and GDM risk
- Outcome
- GDM (genetically predicted causal association of general and central obesity)
Methodological detailsunivariate Mendelian randomization (MR), multivariate MR, MR-based mediation analysis, summary-level GWAS data
- Univariate MR
- Multivariate MR
- MR-based mediation analysis
- Summary-level GWAS data
Main finding
As reported in the abstract
Odds of GDM per 1-SD increase in obesity trait (univariate MR)
- Body mass index (BMI): OR 1.64, P = 5.05 × 10-17
- Waist-to-hip ratio (WHR): OR 1.57, P = 2.27 × 10-14
- WHR adjusted for BMI: OR 1.42, P = 6.11 × 10-15
- Waist circumference: OR 1.64, P = 5.57 × 10-14
- Hip circumference: OR 1.20, P = 0.002
- Heterogeneous associations of waist and hip circumference suggest body fat distribution could influence GDM risk
Further findings
Mediation by circulating lipids
- TG, HDL-C and apolipoprotein A-I each mediated between 5% and 10% of the association between obesity and GDM
Original publication
Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study. Diabetes Res Clin Pract. Published 3 February 2023. doi:10.
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