Gestational diabetes & diabetes in pregnancy
A Prediction Model of Gestational Diabetes Mellitus Based on Oral Glucose Tolerance Test (OGTT) in Early Pregnancy: A Prospective Cohort Study
Authors' conclusion
The existing diagnostic criteria were unsatisfactory for early prediction of GDM. By combining early OGTT, we provided an effective prediction model of GDM in the first trimester.
Study context
- Population
- Pregnant women at Women's Hospital, Zhejiang University School of Medicine, May 30, 2021–August 13, 2022; OGTT at gestational weeks 7–14 for prediction and 24–28 for gestational diabetes mellitus (GDM) diagnosis
- Participants
- 721 women
- Exposure
- Prediction model vs existing diagnostic criteria at weeks 7–14
- Outcome
- Prediction of GDM (diagnosed by OGTT at weeks 24–28)
- Follow-up
- Early OGTT at gestational weeks 7 through 14
Methodological detailsprediction model development, internal and external validation
- Prediction model development
- Internal and external validation
Main finding
As reported in the abstract
Discrimination for GDM (AUC) · weeks 7 through 14
| Group | AUC | AUC internal validation | AUC external validation |
|---|---|---|---|
| Prediction model | 0.8720 | 0.8541 | 0.8241 |
| Existing criteria | 0.705 to 0.724 | — not stated in the abstract | — not stated in the abstract |
AUC
Prediction model0.8720
Existing criteria0.705 to 0.724
AUC internal validation
Prediction model0.8541
Existing criteria— not stated in the abstract
AUC external validation
Prediction model0.8241
Existing criteria— not stated in the abstract
— not stated in the abstract
Observational data: associations, not effects.
Further findings
Age by IADPSG criteria in early OGTT · weeks 7 through 14
Original publication
A Prediction Model of Gestational Diabetes Mellitus Based on OGTT in Early Pregnancy: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 1 February 2023. doi:10.
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