Gestational diabetes & diabetes in pregnancy
Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort
Authors' conclusion
Plasma AAs may be implicated in GDM development starting in early pregnancy. Associations of AAs with GDM may be enhanced in the copresence of phospholipid FA profile.
Study context
- Population
- Pregnant individuals from a longitudinal pregnancy cohort of 2,802cohort of 2,802
- Participants
- 107 vs 214
- Comparison
- Gestational diabetes mellitus (GDM) cases vs non-GDM controls: plasma amino acids (AAs) at 10-14 and 15-26 gestational weeks (GW)
- GDMn = 107
- Non-GDMn = 214reference
- Outcome
- Associations of 24 plasma AAs (and joint associations with phospholipid FAs) with GDM risk
- Follow-up
- 10-14 and 15-26 GW
Main finding
As reported in the abstract
GDM risk per SD increment of plasma AAs · 10-14 GW
Glycine, adjusted OR per SD
0.55 [0.39-0.79] (95% CI)
Alanine, adjusted OR per SD
1.43 [1.08-1.88] (95% CI)
Aspartic acid, adjusted OR per SD
1.41 [1.11-1.80] (95% CI)
Glutamic acid, adjusted OR per SD
1.39 [0.98-1.98] (95% CI)
Observational data: associations, not effects.
Further findings
GDM risk per SD increment of plasma AAs · 15-26 GW
- Isoleucine, adjusted OR per SD
- 1.64 [1.19-2.27] (95% CI)
- Phenylalanine, adjusted OR per SD
- 1.15 [0.87-1.53] (95% CI)
- Tyrosine, adjusted OR per SD
- 1.56 [1.16-2.09] (95% CI)
- Glycine, alanine, aspartic acid and glutamine-to-glutamic acid ratio consistent with directions at 10-14 GW
- All P values for linear trend were <0.05
Joint association of AAs and phospholipid fatty acids (FAs) with GDM · 10-14 GW
- Higher glycine and lower even-chain saturated FAs, adjusted OR (95% CI); lowest risk
- 0.15 [0.06, 0.37]
- Several AAs and phospholipid FAs significantly and jointly associated with GDM
Original publication
Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort. Diabetes Care. Published 26 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →