Gestational diabetes & diabetes in pregnancy

Lifestyle intervention for the prevention of type 2 diabetes in women with prior gestational diabetes: A systematic review and meta‐analysis

Diabetes Obes MetabPublished Systematic review and meta-analysis of randomised trials

Pooled result · Incident T2DResult — go to the resultRelative risk 0.76 95% CI 0.63–0.93

Authors' conclusion

Current published evidence suggests that lifestyle intervention can reduce the risk of T2D in women with prior GD. However, this finding should be interpreted with caution in the presence of documented publication bias.

Study context

Population
Women with previous gestational diabetes (GD); RCTs published 1 January 1950 to 14 December 2022
Participants
3,745 women13 RCTs
Comparison
Lifestyle intervention vs standard care
Outcome
Incident T2D
Methodological detailsfixed-effects model, meta-regression
  • Fixed-effects model
  • Meta-regression

Pooled result

As reported in the abstract

Relative risk

0.76

95% CI 0.63–0.93

Lifestyle interventionvs Standard care
RR 0.76 (95% CI 0.63–0.93)

Further pooled results

Meta-regression: impact of intervention duration and baseline BMI on reduction in incident T2D

No impact of duration of lifestyle intervention
P = 0.81
No impact of baseline BMI
P = 0.90

Publication bias

Evidence of publication bias on funnel plot and Egger test
P = 0.048

Original publication

Lifestyle intervention for the prevention of type 2 diabetes in women with prior gestational diabetes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 17 January 2023. doi:10.1111/dom.14966

Composed by AI from the published abstract and checked against it. How Briefs are made →

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