Gestational diabetes & diabetes in pregnancy
Maternal fasting glucose levels throughout the pregnancy and risk of adverse birth outcomes in newborns: a birth cohort study in Foshan city, Southern China
Authors' conclusion
Our findings indicate higher maternal FPG levels during different trimesters were associated with different adverse birth outcomes, which suggests the importance of glycemic management throughout the pregnancy.
Study context
- Population
- Pregnant women and their offspring in Foshan city, Southern China, November 2015 to January 201945,516 with ≥1 fasting plasma glucose (FPG) test
- Participants
- 63,213 women
- Exposure
- Maternal FPG levels and glycemic fluctuations by trimester
- Outcome
- Adverse birth outcomes: CHD, macrosomia, SGA/LGA and preterm birth (PTB)
Methodological detailsmixed-effects logistic regression
- Mixed-effects logistic regression
Main finding
As reported in the abstract
Adverse birth outcomes per 1 mmol/L increase in maternal FPG
Congenital heart defect (CHD) per 1 mmol/L FPG increase in trimester 1: OR
1.14
95% CI 1.02, 1.26
Preterm birth (PTB) per 1 mmol/L FPG increase in trimester 3: OR
1.05
95% CI 1.01, 1.10
Observational data: associations, not effects.
Further findings
Glycemic fluctuations by trimester and adverse birth outcomes
- Participants with glycemic trajectory data
- 7852
- Similar results to FPG levels
Original publication
Maternal fasting glucose levels throughout the pregnancy and risk of adverse birth outcomes in newborns: a birth cohort study in Foshan city, Southern China. Eur J Endocrinol. Published 13 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →