Gestational diabetes & diabetes in pregnancy
Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence
Main finding · Rapidly increasing skinfold thickness trajectoryResult — go to the resultFold increased risk 6.90 95% CI 1.89–33.32Authors' conclusion
Maternal overweight and GDM are independently and jointly associated with rapidly increasing adiposity trajectories from birth to early adolescence. The findings underscore the importance of considering both maternal metabolic conditions when evaluating offspring adiposity risk.
Study context
- Population
- Mother-child dyads from the Hyperglycemia and Adverse Pregnancy Outcome study Hong Kong field centre; offspring followed from birth to age 9–14 years
- Participants
- 564 mother-child dyads
- Exposure
- Maternal overweight and/or gestational diabetes mellitus (GDM) vs neither
- Outcome
- Offspring adiposity trajectory, primarily assessed by sum of skinfold thickness
- Follow-up
- Birth to median ages of 7 and 10 years
Methodological detailslinear mixed-effect models, group-based trajectory modelling
- Linear mixed-effect models
- Group-based trajectory modelling
Main finding
Rapidly increasing skinfold thickness trajectory · birth to early adolescence
Fold increased risk
6.90
95% CI 1.89–33.32
P = 0.006
As reported in the abstract
- Skinfold thickness trajectories varied significantly by maternal overweight and GDM
- P < 0.05
- Slow increase trajectory group
- 52.1%
- Rapid increase trajectory group
- 47.9%
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| Offspring skinfold thickness trajectory (linear mixed-effect model) · birth to early adolescenceHighest trajectory; reference group not stated | 1.62 (0.69–2.54) | P = 0.001 |
Offspring skinfold thickness trajectory (linear mixed-effect model) · birth to early adolescence
- Greater increases in skinfold thickness among offspring of mothers with either condition
Original publication
Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence. Diabetologia. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →