Gestational diabetes & diabetes in pregnancy
Association between maternal glucose levels in pregnancy and offspring’s metabolism and adiposity: an 18-year birth cohort study
Authors' conclusion
Maternal glucose levels in pregnancy showed a long-term association with offspring's metabolic health into young adulthood, with continuous associations across the full maternal glucose spectrum, suggesting a graded effect of maternal hyperglycaemia on offspring's metabolic risk.
Study context
- Population
- Mother-child pairs from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Hong Kong Field Centre; mothers had 75 g OGTT at 24–32 gestational weeks; offspring assessed at 18 years
- Participants
- 506 mother-child pairs
- Exposure
- Maternal glucose levels in pregnancy; GDM vs normal glucose tolerance
- Outcome
- Offspring's metabolic and adiposity traits
- Follow-up
- 18 years postpartum
Methodological detailsfollow-up of HAPO study, Hong Kong Field Centre, multiple linear and logistic regression
- Follow-up of HAPO study, Hong Kong Field Centre
- Multiple linear and logistic regression
Main finding
As reported in the abstract
- Maternal fasting plasma glucose (FPG) vs offspring FPG, β
- 0.06 (95% CI 0.02, 0.09)
- Maternal 1 h plasma glucose (PG) vs offspring FPG, β
- 0.05
- Maternal 1 h PG vs offspring 30 min PG, β
- 0.21
- Maternal 1 h PG vs offspring 2 h PG, β
- 0.14
- All maternal glycaemic levels associated with increased risk of offspring overweight/obese; maternal 1 h PG, OR
- 1.50 (95% CI 1.17, 1.93)
Observational data: associations, not effects.
Further findings
Offspring abnormal glucose tolerance · up to 18 years · not statistically significant in fully adjusted models
Offspring impaired fasting glucose · up to 18 years · not statistically significant in fully adjusted models
Offspring impaired glucose tolerance · up to 18 years · not statistically significant in fully adjusted models
Original publication
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