Gestational diabetes & diabetes in pregnancy
Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy
Authors' conclusion
FTO risk variants carried by the fetus may indirectly influence maternal metabolism and could be associated with a flatter OGTT curve driven by the reduced 1 h postload PG levels in pregnancy.
Study context
- Population
- Mother-neonate pairs: prior gestational diabetes mellitus (GDM) case-control study (Hungarian-Austrian set) and HAPO study European ancestry subset (HAPO-EUR); Oral glucose tolerance test (OGTT) at 24–28th gestational week
- Comparison
- Fetal FTO risk variant carriers vs non-carriers
- Outcome
- Maternal plasma glucose (PG) levels during OGTT
- Follow-up
- 24-28th gestational week
Methodological detailscase-control (Hungarian-Austrian set), HAPO European ancestry subset, dominant genetic model, adjusted for pre-pregnancy body mass index (BMI) and maternal age, rs8050136 (complete LD with rs9939609) used in HAPO-EUR
- Case-control (Hungarian-Austrian set)
- HAPO European ancestry subset
- Dominant genetic model
- Adjusted for pre-pregnancy BMI and maternal age
- rs8050136 (complete LD with rs9939609) used in HAPO-EUR
Main finding
As reported in the abstract
Maternal 60'min PG
ß Hungarian-Austrian, p = 1.97*10-4
−1.39 mmol/L
ß HAPO-EUR, p = 4.36*10-2
−0.18 mmol/L
ß combined, p = 2.11*10-4
−0.33 mmol/L
Observational data: associations, not effects.
Further findings
Incremental area under glucose curve at OGTT
mmol*h/L
- ß Hungarian-Austrian, p = 3.83*10-4
- −1.70
- ß HAPO-EUR, p = 2.91*10-2
- −0.23
- ß combined, p = 1.61*10-4
- −0.39
- Dominant genetic model
Original publication
Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy. Int J Obes (Lond). Published 28 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →