Gestational diabetes & diabetes in pregnancy
Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study
Authors' conclusion
The correlation between gravida and offspring C-peptide suggests that without crossing the placenta, insulin may influence the offspring pancreatic beta-cell development and insulin sensitivity.
Study context
- Population
- Mother-child dyads from HAPO FUS: pregnancy 3rd-trimester oral glucose tolerance test (OGTT), cord blood, and offspring OGTT at age 10–14 years
- Participants
- 4,121 mother-child dyads
- Exposure
- Gravida fasting and 1-hour OGTT C-peptide vs offspring islet function and insulin sensitivity
- Outcome
- Association of gravida C-peptide with offspring islet function and insulin sensitivity (cord blood and childhood C-peptide, insulin, insulinogenic index, insulin sensitivity, HOMA-IR)
- Follow-up
- Offspring age 10-14 years
Methodological detailsHAPO Follow-up Study, mother-child dyads, multiple linear regression
- HAPO Follow-up Study
- Mother-child dyads
- Multiple linear regression
Main finding
As reported in the abstract
Gravida C-peptide vs offspring measures · 10-14 years of age
Variance explained: maternal C-peptide vs maternal glucose
3.0-17.9 % vs 0.2-3.5 %
Observational data: associations, not effects.
Original publication
Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes Res Clin Pract. Published 21 December 2024. doi:10.
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