Gestational diabetes & diabetes in pregnancy
Renal Function and Risk of Gestational Diabetes Mellitus: The Potential Mediating Role of Carnitine Metabolites
Authors' conclusion
Renal function should be monitored for GDM, and the potential roles of carnitine metabolites require further evaluation and validation.
Study context
- Population
- Pregnant women in the Tongji-Huaxi-Shuangliu Birth Cohort; renal function assessed before 15 gestational weeks; mean age 26.6 ± 3.7 years
- Participants
- 6,770 women
- Exposure
- Extreme quartiles of early-pregnancy renal function indicators
- Outcome
- Gestational diabetes mellitus (GDM) diagnosed by 2-hour OGTT
- Follow-up
- 24 to 28 gestational weeks
Methodological detailsbirth cohort, mediation analysis
- Birth cohort
- Mediation analysis
Main finding
As reported in the abstract
GDM
Odds ratio (95% CI)
Serum uric acidextreme-quartile comparison; positively associated
1.67(1.25–2.23)
Uric acid to creatinine ratioextreme-quartile comparison; positively associated
1.94(1.47–2.57)
eGFRextreme-quartile comparison; positively associated
1.53(1.17–2.01)
Creatinineextreme-quartile comparison; lower GDM risk
0.62(0.47–0.82)
Cystatin Cextreme-quartile comparison; lower GDM risk
0.72(0.52–0.99)
Creatinine to weight ratioextreme-quartile comparison; lower GDM risk
0.69(0.53–0.91)
Observational data: associations, not effects.
Further findings
- Mediation proportion, serum creatinine-related carnitine score
- 43.1%
- Mediation proportion, creatinine to weight ratio-related carnitine score
- 81.9%
- Mediation proportion, estimated glomerular filtration rate (eGFR)-related carnitine score
- 56.7%
- Positive mediating roles
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Renal Function and Risk of Gestational Diabetes Mellitus: The Potential Mediating Role of Carnitine Metabolites. J Clin Endocrinol Metab. Published 18 December 2024. doi:10.
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