Gestational diabetes & diabetes in pregnancy
Blood Cell Parameters From Early to Middle Pregnancy and Risk of Gestational Diabetes Mellitus
Authors' conclusion
Increased WBC, neutrophils, monocytes, and NLR in both early and middle pregnancy and their stable high levels from early to middle pregnancy were associated with higher GDM risk, highlighting that they might be clinically relevant for identifying individuals at high risk for GDM.
Study context
- Population
- Pregnant women in the Tongji-Shuangliu Birth Cohort; blood cell parameters assayed before 15 weeks and between 16 and 28 weeks of gestation445 with gestational diabetes mellitus (GDM)
- Participants
- 6,354 women
- Exposure
- Extreme quartiles of inflammatory blood cell parameters in early and middle pregnancy
- Outcome
- GDM
Methodological detailsbirth cohort, logistic regression
- Birth cohort
- Logistic regression
Main finding
As reported in the abstract
GDM risk by early-pregnancy blood cell parameters, extreme-quartile comparison · early pregnancy (<15 weeks)
- WBC, OR
- 2.38 (1.76-3.20) (95% CI)
- Neutrophils, OR
- 2.47 (1.82-3.36) (95% CI)
- Lymphocytes, OR
- 1.40 (1.06-1.85) (95% CI)
- Monocytes, OR
- 1.69 (1.27-2.24) (95% CI)
- NLR, OR
- 1.51 (1.12-2.02) (95% CI)
- All P for trend
- ≤ .010
Observational data: associations, not effects.
Further findings
GDM risk by higher WBC, neutrophils, monocytes and NLR in middle pregnancy · middle pregnancy (16–28 weeks)
- Associated with increased GDM risk; all P for trend
- ≤ .014
GDM risk by stable high levels (≥ median in early and middle pregnancy) of WBC, neutrophils, monocytes and NLR
- Positively associated with GDM risk; all P
- ≤ .001
Original publication
Blood Cell Parameters From Early to Middle Pregnancy and Risk of Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 6 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →