Gestational diabetes & diabetes in pregnancy

Significance of cell adhesion molecules profile during pregnancy in gestational diabetes mellitus. A systematic review and meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis

Pooled result · Maternal ICAM-1 levelsResult — go to the resultSMD 0.58 95% CI 0.25–0.91

Authors' conclusion

AMs levels were generally higher in GDM participants showing statistical significance maternal ICAM-1 levels (SMD = 0.58, 95% CI = 0.25 to 0.91; p = 0.001).

Study context

Population
Pregnant women with GDM and control pregnant women; PubMed, Embase, Web of Science and Scopus searched19 studies
Participants
765 vs 2,368
Comparison
GDM vs control pregnant women
  • GDMn = 765
  • Controln = 2,368reference
Outcome
Maternal ICAM-1 levels
Methodological detailsNewcastle-Ottawa scale quality assessment, heterogeneity and publication bias examined
  • Newcastle-Ottawa scale quality assessment
  • Heterogeneity and publication bias examined

Pooled result

As reported in the abstract

SMD

0.58

95% CI 0.25–0.91

P = 0.001

GDMvs Control
SMD 0.58 (95% CI 0.25–0.91); P = 0.001

Further pooled results

No significant differences in subgroups or meta-regression analyses

Original publication

Significance of cell adhesion molecules profile during pregnancy in gestational diabetes mellitus. A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 3 June 2023. doi:10.1016/j.diabres.2023.110740

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