Gestational diabetes & diabetes in pregnancy
Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus
Authors' conclusion
Women with overweight or obesity and GDM, compared with those without GDM, have worse IS and β-cell function early during pregnancy and a greater subsequent decline in IS and blunted increase in β-cell function. Increased fasting and 1-h OGTT plasma glucose concentration early during pregnancy are markers of increased GDM risk, albeit with weak predictive power.
Study context
- Population
- Pregnant women with overweight or obesity
- Participants
- 29 vs 164
- Exposure
- Gestational diabetes mellitus (GDM) vs No-GDM
- GDMn = 29
- No-GDMn = 164reference
- Outcome
- IS (Matsuda index), β-cell function and OGTT plasma glucose
- Follow-up
- 15 weeks
Methodological detailsfrequently sampled oral glucose tolerance test (OGTT) at 15 and 35 weeks' gestation
- Frequently sampled OGTT at 15 and 35 weeks' gestation
Main finding
As reported in the abstract
- GDM vs No-GDM: all P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Change from 15 to 35 weeks in IS, β-cell function and postprandial FFA | all P ≤ 0.05 |
- Change from 15 to 35 weeks in insulin sensitivity (IS), β-cell function and postprandial free fatty acid (FFA): greater decrease in IS, greater increase in postprandial FFA, smaller increase in β-cell function with GDM
Change from 15 to 35 weeks in IS, β-cell function and postprandial FFA
- In both groups IS decreased, β-cell function increased and postprandial FFA suppression was blunted
Prediction of GDM by FPG and 1-h OGTT glucose at 15 weeks (ROC analysis)
- Both predictors of GDM; predictive power
- <30%
Original publication
Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus. Diabetes Care. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →