Gestational diabetes & diabetes in pregnancy
Risk Estimation of Gestational Diabetes Mellitus in the First Trimester
Authors' conclusion
Based on these measurements, we accurately predict the development of later-onset GDM (24th-28th weeks of pregnancy). Early risk estimation provides the opportunity for targeted prevention and the timely treatment of GDM. Prevention and slowing the progression of GDM result in a lower lifelong metabolic risk for both mother and offspring.
Study context
- Population
- Pregnant women from a Hungarian biobank cohort (2545 pregnant women); serum/plasma samples collected at the end of the first trimesterbiobank cohort of 2545
- Participants
- 55 vs 55
- Comparison
- Women who later developed gestational diabetes mellitus (GDM) vs randomly selected controls
- GDMn = 55
- Controln = 55reference
- Outcome
- First-trimester prediction markers for later GDM
- Follow-up
- End of first trimester
Methodological detailsnested in Hungarian biobank cohort
- Nested in Hungarian biobank cohort
Main finding
As reported in the abstract
GDM prediction model (forward stepwise multivariate logistic regression; fructosamine, cortisol, cortisone, 11-deoxycorticosterone, SuPAR)
Specificity
96.6%
Sensitivity
97.5%
Observational data: associations, not effects.
Further findings
First-trimester characteristics and serum/plasma markers · end of first trimester
- Women who later developed GDM were older and had higher BMI
- Higher in GDM: fructosamine, total antioxidant capacity, testosterone, cortisone, 21-deoxycortisol
- Lower in GDM: soluble urokinase plasminogen activator receptor, DHEAS, dihydrotestosterone, cortisol, 11-deoxycorticosterone
Original publication
Risk Estimation of Gestational Diabetes Mellitus in the First Trimester. J Clin Endocrinol Metab. Published 29 May 2023. doi:10.
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