Gestational diabetes & diabetes in pregnancy
Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes
Authors' conclusion
Differences between nonobese and obese GDM, or obese non-GDM women and controls in metabolomic profiles may allow detection of high-risk women for timely targeted preventive interventions.
Study context
- Population
- Pregnant women from the PREDO and RADIEL studies; 66 metabolic measures in early (median 13, IQR 12.4–13.7 gestation weeks), mid (20, 19.3–23.0) and late (28, 27.0–35.0) pregnancy blood samplesreplication cohort 490
- Participants
- 755 women
- Exposure
- Nonobese gestational diabetes mellitus (GDM), obese GDM and obese non-GDM vs nonobese non-GDM controls
- Outcome
- Metabolomic profiles (66 metabolic measures)
- Follow-up
- Early, mid and late pregnancy
Methodological detailsmetabolomic analysis, independent replication cohort
- Metabolomic analysis
- Independent replication cohort
Main finding
As reported in the abstract
Nonobese and obese GDM and obese non-GDM differed similarly from controls, incl. VLDL-related measures and fatty acids
13 measures
Differences more pronounced for obese GDM vs controls than for nonobese GDM or obese non-GDM vs controls, incl. Fatty acid (FA) ratios, glycolysis-related measures, valine, 3-hydroxybutyrate
6 measures
Differences more pronounced for obese GDM or obese non-GDM vs controls than for nonobese GDM vs controls, incl. HDL-related measures, FA ratios, amino acids, inflammation
16 measures
Observational data: associations, not effects.
Further findings
Replication cohort
- Differences more often in the same direction than expected by chance alone
Original publication
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