Gestational diabetes & diabetes in pregnancy
Non-efficacy of early intervention strategy for non-obese patients with early-onset gestational diabetes mellitus: solely based on the short-term outcomes
Authors' conclusion
The strategy for diagnosing GDM by IADPSG thresholds in early pregnancy and providing treatment to all patients from early pregnancy did not improve the pregnancy outcomes, but rather increased the SGA rate.
Study context
- Population
- Women with a singleton pregnancy diagnosed with early-onset gestational diabetes mellitus (GDM) by 20 weeks of gestation by International Association of Diabetes and Pregnancy Study Group (IADPSG) threshold
- Participants
- 286 vs 248
- Exposure
- Treatment from early pregnancy vs treatment from mid-pregnancy
- Treatment from early pregnancyn = 286
- Treatment from mid-pregnancyn = 248reference
- Outcome
- LGA
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
SGA · higher with treatment from early pregnancy
P = 0.046
- False-positive early GDM in treatment from mid-pregnancy · second oral glucose tolerance test (OGTT) at 24-28 weeks
- 50% · 124 of 248
Neonatal outcomes
- No significant differences in neonatal outcomes between groups
Large for gestational age (LGA), subgroup BMI >25 kg/m²
- LGA significantly lower with treatment from early pregnancy than from mid-pregnancy
Safety
- No significant differences in maternal adverse events between groups
Original publication
Non-efficacy of early intervention strategy for non-obese patients with early-onset gestational diabetes mellitus: solely based on the short-term outcomes. BMJ Open Diabetes Res Care. Published 2 June 2023. doi:10.
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