Gestational diabetes & diabetes in pregnancy
Probiotics and dietary fibre fermented milk supplementation initiated in the first trimester to prevent gestational diabetes mellitus in overweight and obese pregnant women: A randomized controlled trial
Primary result · GDM incidenceResult — go to the resultOdds ratio 0.45 95% CI 0.25–0.83Authors' conclusion
PFM supplementation initiated in the first trimester reduced GDM incidence. IDL reduced weight gain but had no significant effect on GDM. PFM may be a promising strategy for GDM prevention in these high-risk populations.
Study context
- Population
- Overweight and obese pregnant women (prepregnancy BMI ≥25 kg/m²) enrolled at 6–12+6 weeks of gestation
- Participants
- 478 participants
- Comparison
- Intensive dietary and lifestyle (IDL) interventions vs PFM supplementation vs standard care, initiated in the first trimester
- Primary endpoint
- GDM
Methodological detailsparallel
- Parallel
Primary result
GDM incidence
Odds ratio
0.45
95% CI 0.25–0.83
Events by treatment group
PFMvs SC
OR 0.45 (95% CI 0.25–0.83)
As reported in the abstract
Secondary outcomes
Weight gain at time of OGTT — between IDL and PFM · across IDL, PFM and SC; lower with IDL
P = 0.009
Gut microbiota correlations
- Acidovorax abundance in PFM negatively associated with oral glucose tolerance test (OGTT) 0 h glucose; Megasphaera in standard care (SC) positively correlated with 2-hour post-load glucose
- P < 0.05
Original publication
Probiotics and dietary fibre fermented milk supplementation initiated in the first trimester to prevent gestational diabetes mellitus in overweight and obese pregnant women: A randomized controlled trial. Diabetes Obes Metab. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →