Gestational diabetes & diabetes in pregnancy
Higher Maternal Body Mass Index Is Associated With Lower Placental Expression ofEPYC:A Genome-Wide Transcriptomic Study
Authors' conclusion
Our genome-wide transcriptomic study revealed novel genes potentially implicated in placental biologic response to higher maternal BMI in early pregnancy.
Study context
- Population
- Pregnant participants of the Gen3G prospective cohort enrolled at 5 to 16 weeks of gestation; placenta collected at delivery; mean ± SD age 28.2 ± 4.4 years, body mass index (BMI) 25.4 ± 5.5 kg/m²
- Participants
- 450 placental samples
- Exposure
- Continuous first-trimester maternal BMI (log2); secondary: obesity (BMI ≥30 kg/m²) vs BMI 18.5–24.9
- Obesityn = 82
- BMI 18.5 to 24.9n = 257reference
- Outcome
- Change in normalized placental gene expression (>15 000 genes) per 1-unit increase in log2 BMI, adjusted for maternal age, fetal sex, gestational age at delivery, gravidity and surrogate variables
Methodological detailsgenome-wide transcriptomic, whole-genome RNA sequencing
- Genome-wide transcriptomic
- Whole-genome RNA sequencing
Main finding
As reported in the abstract
Placental EPYC expression per 1-unit increase in log2 BMI
Higher maternal BMI associated with lower placental EPYC expression (slope)
−1.94
FDR-adjusted P = 7.3 × 10-6
Observational data: associations, not effects.
Further findings
| Outcome | log2 fold change | P value |
|---|---|---|
| Placental EPYC expression, obesity vs BMI 18.5–24.9 | −1.35 | FDR-adjusted P = 3.4 × 10-3 |
Original publication
Higher Maternal Body Mass Index Is Associated With Lower Placental Expression ofEPYC:A Genome-Wide Transcriptomic Study. J Clin Endocrinol Metab. Published 21 October 2023. doi:10.
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