Gestational diabetes & diabetes in pregnancy

Third-Trimester Energy-Restriction or Weight Loss and Maternal and Child Body Composition One Year Postnatally After a Pregnancy With Gestational Diabetes: Results From the DiGest Follow-up Study

Diabetes CarePublished Follow-up study of the DiGest randomised controlled trial

Authors' conclusion

Among women with gestational diabetes and high BMI, energy restriction or weight loss in pregnancy were associated with no adverse effects on offspring weight or growth in the first year.

Study context

Population
Women with GDM and BMI ≥25 kg/m², follow-up to 12 months postnatally
Comparison
Reduced-energy (1,200 kcal/day) vs standard-energy (2,000 kcal/day) diet in the third trimester; and pregnancy weight loss vs no weight loss (cohort analysis)
Primary endpoint
Maternal and offspring weight postnatally
Follow-up
Up to 12 months postnatally
Methodological detailstrial and cohort analyses, adjusted linear and logistic regression, Super-Imposition by Translation and Rotation model
  • Trial and cohort analyses
  • Adjusted linear and logistic regression
  • Super-Imposition by Translation and Rotation model

Primary result

As reported in the abstract

Antenatal and postnatal growth by randomised allocation · first year of life
  • Allocation to energy restriction did not alter antenatal or postnatal growth; infants in both groups had normal weight for age throughout the first year
  • Trial analysis

Further findings

Maternal weight in women who lost weight in pregnancy (cohort analysis) · 3 and 12 months

Average pregnancy weight loss
3 kg
Lower adjusted maternal weight at 3 but not 12 months
  • Cohort analysis

Infant outcomes after exposure to pregnancy weight loss (cohort analysis)

Lower risk of large-for-gestational age at birth
Lower fat mass at 3 months
No evidence of growth faltering or excessive catch-up or catch-down growth
  • Cohort analysis

Safety

Low infant weight after exposure to pregnancy weight loss

No higher prevalence of low infant weight; weight for age < −2 SD
<5%
  • Cohort analysis

Original publication

Third-Trimester Energy-Restriction or Weight Loss and Maternal and Child Body Composition One Year Postnatally After a Pregnancy With Gestational Diabetes: Results From the DiGest Follow-up Study. Diabetes Care. Published 27 August 2026. doi:10.2337/dc26-0405

Composed by AI from the published abstract and checked against it. How Briefs are made →

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