Gestational diabetes & diabetes in pregnancy
Limosilactobacillus reuteri and Lactobacillus johnsonii intervention ameliorates gestational diabetes mellitus-associated sex-specific placental nutrient transporter abnormalities: Links with tryptophan metabolism and aryl hydrocarbon receptor signaling
Authors' conclusion
Combined L. reuteri and L. johnsonii intervention improved GDM-associated maternal metabolic and sex-specific placental abnormalities.
Study context
- Population
- Normal and gestational diabetes mellitus (GDM) pregnant women (fecal metagenomics); GDM mouse model
- Comparison
- Combined L. reuteri and L. johnsonii intervention vs no intervention in GDM mice
Methodological detailsmetagenomic sequencing, GDM mouse model
- Metagenomic sequencing
- GDM mouse model
Main finding
As reported in the abstract
- Reduced Lactobacillaceae in GDM women; L. reuteri and L. johnsonii identified as candidates
- Intervention improved glycemic control, insulin resistance, inflammation and colon barrier function, and alleviated placental lesions
- Sex-specific abnormalities in placental nutrient transporter expression normalized by probiotics
- Maternal plasma 5-HIAA reduced in GDM mice and restored after intervention, correlating with metabolic indices, placental status, fetal growth and aryl hydrocarbon receptor (AhR) signaling
Original publication
Limosilactobacillus reuteri and Lactobacillus johnsonii intervention ameliorates gestational diabetes mellitus-associated sex-specific placental nutrient transporter abnormalities: Links with tryptophan metabolism and aryl hydrocarbon receptor signaling. Diabetes Res Clin Pract. Published 25 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →