Gestational diabetes & diabetes in pregnancy
Associations of Circadian‐Disruptive Behaviours With Plasma Glycemic Parameters and Continuous Glucose Monitoring Measures Among Pregnant Women
Authors' conclusion
Higher CDB burden was associated with less favourable glycemic profiles and lower HOMA2-%B during pregnancy.
Study context
- Population
- Pregnant women recruited at 18–24 weeks' gestation; Circadian-disruptive behaviours (CDBs) (eating jetlag, predominant night-eating, social jetlag, electronic media use before bedtime) assessed by dietary records and questionnaires
- Participants
- 246 women
- Exposure
- Number of circadian-disruptive behaviours vs no CDBs
- Outcome
- Oral-glucose-tolerance-test (OGTT) and insulin parameters (24-28 weeks' gestation) and CGM metrics (18-24 weeks' gestation)
Main finding
As reported in the abstract
24-28 weeks' gestation
Each group vs no CDBsEstimate (95% CI)
Two CDBs
geometric mean ratio, fasting insulin 1.23(1.02–1.48)
Two CDBs
geometric mean ratio, HOMA2-IR 1.23(1.02–1.47)
Three or four CDBs
geometric mean ratio, fasting glucose 1.09(1.04–1.15)
Three or four CDBs
geometric mean ratio, 1-h glucose 1.17(1.03–1.33)
Three or four CDBs
geometric mean ratio, glucose AUC 1.14(1.03–1.26)
Three or four CDBs
geometric mean ratio, HOMA2-%B 0.76(0.62–0.93)
Observational data: associations, not effects.
Further findings
Continuous-glucose-monitoring (CGM) glycemic control measures (mean glucose, glucose management indicator (GMI), J-index) by fetal sex · 18-24 weeks' gestation
- Fetal sex modified associations of CDBs with mean glucose, GMI and J-index
- all p interaction < 0.1
- Higher cumulative CDB measure significantly associated with higher glycemic control measures in women carrying female foetuses
- Stratified analyses
Original publication
Associations of Circadian‐Disruptive Behaviours With Plasma Glycemic Parameters and Continuous Glucose Monitoring Measures Among Pregnant Women. Diabetes Obes Metab. Published 25 August 2026. doi:10.
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