Gestational diabetes & diabetes in pregnancy
Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus
Authors' conclusion
miR-515-5p, specifically encapsulated within EVs from omental adipose tissue in GDM, regulates placental nutrient uptake, glucose homeostasis, and fetal growth.
Study context
- Population
- Pregnant women with normal glucose tolerance (NGT) or gestational diabetes mellitus (GDM); omental adipose tissue and derived extracellular vesicles (EVs); trophoblast cells and pregnant mice
- Participants
- 36 vs 20
- Comparison
- Omental adipose tissue EVs from GDM vs NGT
- GDMn = 36
- NGTn = 20reference
- Outcome
- miRNA profile of adipose tissue EVs and effects on trophoblasts and fetal growth
Methodological detailsmiRNA expression profiling, in vitro trophoblast experiments, in vivo pregnant mouse experiments
- miRNA expression profiling
- In vitro trophoblast experiments
- In vivo pregnant mouse experiments
Main finding
As reported in the abstract
- MicroRNAs (miRNAs) significantly different between EVs from NGT and GDM adipose tissue
- 54
Observational data: associations, not effects.
Original publication
Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus. Cardiovasc Diabetol. Published 14 May 2025. doi:10.
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