Gestational diabetes & diabetes in pregnancy
Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis
Authors' conclusion
Our results suggest that the ADsEV miRNAs in mothers are potential regulators of fetal adiposity. The expression and functionality of miRNAs appear to be influenced by maternal adiposity, hyperglycemia, and micronutrient status during pregnancy.
Study context
- Population
- Mother-neonate pairs (NGT = 148, GDM = 131) with all phenotypic data; adipocyte-derived small extracellular vesicular miRNAs in maternal and cord blood
- Participants
- 279 mother-neonate pairs
- Comparison
- Neonates with adiposity vs lean
- Adiposen = 76
- Leann = 51reference
- Outcome
- Differential expression of ADsEV miRNAs in adipose vs lean groups, before and after adjustment for maternal GDM, adiposity and vitamin B12-folate status
Methodological detailsdiscovery analysis, microarray profiling
- Discovery analysis
- Microarray profiling
Main finding
As reported in the abstract
Differentially expressed ADsEV miRNAs (discovery p ≤ 0.1), adipose vs lean
Maternal miRNAs differential expression (DE), unadjusted
24
Cord blood miRNAs DE, unadjusted
5
Maternal miRNAs DE, adjusted
19
Cord blood miRNAs DE, adjusted
26
Further findings
Maternal-cord blood miRNA correlation
- Multiple miRNAs were common in maternal and cord blood and positively correlated
Maternal factors
- Maternal GDM and adiposity were associated with many DE adipocyte-derived small extracellular vesicular (ADsEV) miRNAs
Original publication
Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis. Int J Obes (Lond). Published 13 December 2023. doi:10.
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