Gestational diabetes & diabetes in pregnancy

Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial

Nat MedPublished Randomised controlled trial

Authors' conclusion

A reduced-energy diet was safe in pregnancy.

Study context

Population
Women with singleton pregnancies, GDM and BMI ≥25 kg m-2388 analysed at 36 weeks
Participants
425 women
Comparison
Reduced-energy diet vs standard-energy control diet
  • Interventionn = 214
  • Controln = 211reference
Primary endpoint
Maternal weight change from enrollment to 36 weeks and offspring birth weight
Follow-up
36 weeks; delivery
Methodological detailsmulticentre, parallel, double-blind, 1:1 randomization stratified by center
  • Multicentre
  • Parallel
  • Double-blind
  • 1:1 randomization stratified by center

Primary result

As reported in the abstract

Each group vs controlIntervention effect (maternal weight change to 36 weeks) (95% CI)P value
Intervention
−0.20(−1.01 to 0.61)
P > 0.1
Intervention
intervention effect (offspring standardized birth weight) 0.005 (95% CI −0.19 to 0.20); P > 0.1

Safety

Reduced-energy diet was safe in pregnancy

Original publication

Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial. Nat Med. Published 19 February 2025. doi:10.1038/s41591-024-03356-1

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