Gestational diabetes & diabetes in pregnancy
Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort
Authors' conclusion
High levels of ApoB and low levels of ApoD in early pregnancy were independently associated with an increased risk of GDM, insulin resistance, and large-for-gestational-age infants (low ApoD only), suggesting potential roles for future management of pregnancy outcomes.
Study context
- Population
- Pregnant women in the population-based Odense Child Cohort, followed from inclusion until childbirth; 12 apolipoproteins measured by targeted proteomics (LC-MS) on late first trimester serum; Gestational diabetes mellitus (GDM) by WHO 2013 criteria415 (41.9%) with GDM
- Participants
- 991 women
- Exposure
- Early-pregnancy serum apolipoprotein levels vs risk of GDM
- Outcome
- GDM
Methodological detailsobservational, population-based
- Observational
- Population-based
Main finding
As reported in the abstract
Adjusted odds ratio
1.26
P = 0.002
Increasing ApoB
Adjusted odds ratio
0.84
P = 0.021
Increasing ApoD
Observational data: associations, not effects.
Further findings
| Outcome | aOR | P value |
|---|---|---|
| Large-for-gestational-age infants | 0.78 | P = 0.041 |
Correlation of early-pregnancy ApoB and ApoD with third-trimester insulin resistance and beta-cell function
- ApoB vs insulin resistance, r
- 0.22, P < .001
- ApoB vs beta-cell function, r
- 0.20, P < .001
- ApoD vs insulin resistance, r
- −0.14, P < .001
- ApoD vs beta-cell function, r
- −0.12, P < .001
Original publication
Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort. Endocr Pract. Published 17 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →