Gestational diabetes & diabetes in pregnancy
The cardio‐metabolic protein profile is associated with development of type 2 diabetes at long term follow‐up after gestational diabetes mellitus: Results from the Odense GDM Follow-Up Study (OGFUS) study
Authors' conclusion
The cardio-metabolic protein profile 8-10 years after pregnancy is altered in women with previous GDM. Apolipoprotein D, vitronectin and complement factors 3 and B are candidate risk markers of type 2 diabetes after GDM pregnancy.
Study context
- Population
- Women from the Odense gestational diabetes mellitus (GDM) Follow-Up Study (OGFUS) cohort; blood samples 8–10 years after delivery analysed with a 29-plex panel of apolipoproteins, transport and inflammation/immune proteins (multiple-reaction-monitoring mass spectrometry)
- Participants
- 128 vs 70
- Comparison
- Previous GDM vs matched controls without previous GDM
- Previous GDMn = 128
- Controlsn = 70reference
- Outcome
- Cardio-metabolic protein profile and its association with development of T2D after GDM
- Follow-up
- 8-10 years after delivery
Methodological detailsmatched controls, based on the OGFUS cohort
- Matched controls
- Based on the OGFUS cohort
Main finding
As reported in the abstract
Cardio-metabolic protein levels, previous GDM vs controls
- Apolipoprotein A-I, D and M significantly lower in previous GDM vs controls
- all p < 0.001
- Apolipoprotein L-I, H, vitamin D binding protein, CRP, vitronectin, transthyretin and complement factors 3 and B significantly higher in previous GDM
- p = 0.008, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.005, respectively
Observational data: associations, not effects.
Further findings
Association with development of T2D in women with previous GDM
- Apolipoprotein D, vitronectin and complement factors 3 and B associated with development of T2D
- P = 0.02, p = 0.001, p < 0.001, p = 0.004, respectively
Original publication
The cardio‐metabolic protein profile is associated with development of type 2 diabetes at long term follow‐up after gestational diabetes mellitus: Results from the OGFUS study. Diabetes Obes Metab. Published 2 January 2025. doi:10.
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