Gestational diabetes & diabetes in pregnancy
Association between polycystic ovary syndrome and pregnancy outcomes in gestational diabetes mellitus (GDM): A secondary analysis of the DiGest trial
Authors' conclusion
In women with GDM, PCOS was not associated with increased risks for most suboptimal pregnancy outcomes or reduced efficacy of a dietary intervention in this cohort where BMI and glycemia were comparable.
Study context
- Population
- Pregnant women with GDM and BMI ≥25 kg/m², 8 UK centres; randomised to reduced-energy diet (1200 kcal/day) or standard-energy control diet (2000 kcal/day) from 29 weeks until delivery
- Participants
- 425 women
- Comparison
- Polycystic ovary syndrome (PCOS) vs no PCOS in women with GDM
- PCOSn = 50
- No PCOSn = 375reference
- Primary endpoint
- Pregnancy outcomes, incl. maternal weight, CGM metrics, physical and dietary data, infant birthweight and jaundice
Methodological detailsdouble-blind, multicentre
- Double-blind
- Multicentre
Primary result
As reported in the abstract
Pregnancy outcomes
- Similar baseline characteristics, glycaemia, BMI and pregnancy outcomes in PCOS vs GDM alone
Further findings
Neonatal jaundice
P = 0.002
Outcomes across dietary interventions
- Outcomes across the dietary interventions were similar in women with and without PCOS
Original publication
Association between polycystic ovary syndrome and pregnancy outcomes in GDM: A secondary analysis of the DiGest trial. J Clin Endocrinol Metab. Published 28 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →