Gestational diabetes & diabetes in pregnancy
An oral glucose tolerance test in pregnancy and its association with future cardiovascular diseases
Authors' conclusion
A history of abnormal 100-gram OGTT results during pregnancy, and specifically having four abnormal values, is associated with an elevated risk of CVD. These results underscore the need for early post-partum identification and prevention strategies in this high-risk population.
Study context
- Population
- Pregnant individuals aged 20–50 years without prior T2D or cardiovascular disease (CVD), with a complete 100-g oral glucose tolerance test (OGTT) during their last pregnancy (January 2000–December 2022), major Israeli healthcare provider; mean age 34 ± 5.2 years
- Participants
- 103,389 individuals
- Exposure
- Number of abnormal 100-g OGTT values in pregnancy vs all values normal
- Outcome
- Development of a composite of CVD
- Follow-up
- By September 2024
Main finding
As reported in the abstract
Composite CVD · median follow-up 6.8 years (IQR, 3.4-12.9)
Each group vs all OGTT values normalAdjusted hazard ratio (95% CI)
One to three abnormal values
1.2(1.02–1.4)
Four abnormal OGTT values
2.41(1.44–4.05)
- Composite CVD, overall (cumulative incidence 0.62%)
- 641
Observational data: associations, not effects.
Original publication
An oral glucose tolerance test in pregnancy and its association with future cardiovascular diseases. Diabetes Obes Metab. Published 26 January 2026. doi:10.
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