Gestational diabetes & diabetes in pregnancy
Future diabetes risk can be predicted by the number of abnormal oral glucose tolerance test values during pregnancy
Authors' conclusion
GD is a heterogenous disease, with varying degrees of glucose intolerance and subsequent T2D risk. Targeting interventions to women at the highest risk may help to improve postpartum adherence and effective long-term follow-up strategies.
Study context
- Population
- Pregnant women tested for gestational diabetes (GD) with a 100-g oral glucose tolerance test (OGTT) (0, 60, 120, 180 min) in a large health maintenance organization in Israel9,939 met criteria
- Participants
- 10,023 women
- Exposure
- GD vs no GD; number of abnormal 100-g OGTT values
- Outcome
- Future T2D
- Follow-up
- Median 3.25 years (IQR 1.5-5.1; maximum 10.1)
Main finding
As reported in the abstract
Each group vs without GDHazard ratio (95% CI)
GD
5.33(3.86–7.34)
Four abnormal OGTT valueshighest risk
16.67(7.94–35.01)
Observational data: associations, not effects.
Further findings
Future T2D by type of OGTT abnormality
- Abnormal fasting value (greatest risk), HR
- 3.61 (2.42-5.38) (95% CI)
- Abnormal 3-hour value (lowest risk), HR
- 1.50 (0.93-2.43) (95% CI)
Multivariate predictors of future T2D
- Higher number of abnormal values, Arab ethnicity, higher BMI, TG and prepregnancy glucose significantly associated with increased risk
- Multivariate model
Original publication
Future diabetes risk can be predicted by the number of abnormal oral glucose tolerance test values during pregnancy. Diabetes Obes Metab. Published 19 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →