Gestational diabetes & diabetes in pregnancy
Kidney Disease in Women With Previous Gestational Diabetes Mellitus: A Nationwide Register-Based Cohort Study
Main finding · CKDResult — go to the resultAdjusted hazard ratio 1.92 95% CI 1.67–2.21Authors' conclusion
The risk of CKD was significantly elevated after GDM irrespective of subsequent development of diabetes and hypertension. Furthermore, women with severe metabolic dysfunction during pregnancy had the highest CKD risk.
Study context
- Population
- All women giving birth in Denmark between 1997 and 2018
- Participants
- 697,622 women
- Exposure
- Previous gestational diabetes mellitus (GDM) vs no GDM
- Outcome
- Incident kidney disease: CKD and acute kidney disease, based on diagnosis codes
- Follow-up
- Median 11.9 years
Methodological detailsDanish, Cox regression, mediation analyses
- Danish
- Cox regression
- Mediation analyses
Main finding
CKD
Adjusted hazard ratio
1.92
95% CI 1.67–2.21
GDMvs No GDM
aHR 1.92 (95% CI 1.67–2.21)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| CKD in insulin-treated GDM without subsequent diabetesInsulin-treated GDM, no subsequent diabetesvs No GDM | 2.35 (1.39–3.97) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Mediation of GDM–chronic kidney disease (CKD) association: proportion of indirect effect
- Diabetes
- 75.7% (95% CI 61.8-89.6)
- Hypertension
- 30.3% (95% CI 25.2-35.4)
Original publication
Kidney Disease in Women With Previous Gestational Diabetes Mellitus: A Nationwide Register-Based Cohort Study. Diabetes Care. Published 15 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →