Gestational diabetes & diabetes in pregnancy
Childhood adversity and gestational diabetes: examining the mediating effect of BMI and depression through interventional mediation analysis
Main finding · Reduction in absolute GDM risk by intervening on BMI (equalising to low adversity distribution)Result — go to the resultReduction in absolute GDM risk 0.12 % 95% CI 0.10–0.14Authors' conclusion
Intervening on pre-pregnancy BMI might potentially reduce the risk of GDM for mothers in some of the adversity groups, whereas intervening on depression seems to have little impact. The findings suggest that high adversity likely increases the risk of GDM through alternative mechanisms than BMI or depression.
Study context
- Population
- All women born in Denmark giving birth for the first time, 2004–2018; five previously identified adversity trajectory groups
- Participants
- 207,659 women
- Exposure
- Childhood adversity trajectory groups vs low adversity; mediation via pre-pregnancy BMI and depression
- Outcome
- GDM risk reduction mediated by pre-pregnancy BMI and depression
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Reduction in absolute GDM risk by intervening on BMI (equalising to low adversity distribution)
Reduction in absolute gestational diabetes mellitus (GDM) risk
0.12 %
95% CI 0.10–0.14
Observational data: associations, not effects.
Further findings
GDM incidence · 2004–2018
- Women diagnosed with GDM
- 4779
- Absolute risk of GDM
- 2.3%
Original publication
Childhood adversity and gestational diabetes: examining the mediating effect of BMI and depression through interventional mediation analysis. Int J Obes (Lond). Published 16 April 2026. doi:10.
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