Gestational diabetes & diabetes in pregnancy
An Oral Glucose Tolerance Test in Pregnancy Can Serve as a Valuable Predictor for Future Diabetes
Authors' conclusion
The number and type of abnormal OGTT results strongly predict future T2D. These findings can inform targeted postpartum interventions and predictive tools for early prevention in high-risk women.
Study context
- Population
- Women aged 20–50 years without prior T2D with a complete 100-g oral glucose tolerance test (OGTT) during their last pregnancy (2000–2022), major Israeli healthcare provider; age 34.1 ± 5.2 years, BMI 27.6 ± 5.3 kg/m²
- Participants
- 107,889 women
- Exposure
- Number and type of abnormal 100-g OGTT values in pregnancy vs all values normal
- Outcome
- Development of T2D
- Follow-up
- By September 2024
Methodological detailssingle healthcare provider database, Cox proportional hazards models
- Single healthcare provider database
- Cox proportional hazards models
Main finding
As reported in the abstract
T2D risk by number of abnormal OGTT values · median follow-up 6.7 years (IQR 3.3-12.4)
Each group vs all OGTT values normalHazard ratio (95% CI)
1 abnormal value
3.45(3.15–3.77)
2 abnormal values
4.03(3.69–4.41)
3 abnormal values
7.15(6.49–7.88)
4 abnormal values
10.60(9.28–12.20)
- T2D developed (overall)
- 4500 women (0.5%)
Observational data: associations, not effects.
Further findings
T2D risk by type of abnormal OGTT value
- Abnormal fasting glucose, HR
- 5.28 (95% CI 4.83-5.76)
- Abnormal nonfasting values, HR
- 3.03 (95% CI 2.78-3.29)
- Abnormal fasting glucose associated with a higher risk than abnormal nonfasting values
Previous gestational diabetes mellitus (GDM) diagnosis
- Previous GDM significantly associated with future T2D risk, even with no current abnormal OGTT values
Original publication
An Oral Glucose Tolerance Test in Pregnancy Can Serve as a Valuable Predictor for Future Diabetes. J Clin Endocrinol Metab. Published 26 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →