Gestational diabetes & diabetes in pregnancy
Reduced serum acetyl-L-carnitine is associated with hypertensive disorders in women with gestational diabetes mellitus: a multi-omics study
Authors' conclusion
Reduced serum ALC at 24-28 weeks of gestation was reproducibly associated with GDM complicated by HDP. Combining ALC with DBP improved discrimination between GDMHDP and uncomplicated GDM, suggesting complementary metabolic and hemodynamic information.
Study context
- Population
- Women with gestational diabetes mellitus (GDM); serum sampled at 24–28 weeks of gestationdiscovery n = 128
- Exposure
- GDMHDP vs GDM
- Outcome
- Serum acetyl-L-carnitine (ALC) and combined ALC-DBP model
- Follow-up
- 24-28 weeks of gestation
Methodological detailsmulti-omics, discovery and validation cohorts, single-center
- Multi-omics
- Discovery and validation cohorts
- Single-center
Main finding
As reported in the abstract
24-28 weeks of gestation
ALC-DBP model AUC, discovery cohort
0.907
ALC-DBP model AUC, validation cohort
0.886
Observational data: associations, not effects.
Further findings
Lipid associations
- Lower acetyl-L-carnitine (ALC) associated with selected ceramide and monolysocardiolipin species and lipid patterns consistent with altered fatty-acid handling; DBP showed a partly distinct pattern of lipid correlations
Original publication
Reduced serum acetyl-L-carnitine is associated with hypertensive disorders in women with gestational diabetes mellitus: a multi-omics study. Cardiovasc Diabetol. Published 26 August 2026. doi:10.
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