Gestational diabetes & diabetes in pregnancy
Maternal coronary heart disease and mortality following hypertensive disorders of pregnancy and/or diabetes
Authors' conclusion
Within 5 years of delivery, incident CHD and all-cause mortality rates were highest for women with two or three conditions, specifically HDP, diabetes, and/or pre-pregnancy HTN, with all rates higher for NHB than NHW women. Thus, it is critical to implement clinical prevention strategies to improve risk factor screening and identification among women of child-bearing age.
Study context
- Population
- Women aged 12–49 with ≥ 1 singleton live birth in South Carolina (2004–2016); Non-Hispanic White (NHW) 59.2%, non-Hispanic Black (NHB) 31.4%, Hispanic 9.4%
- Participants
- 430,545 women
- Exposure
- Diabetes, hypertensive disorders of pregnancy (HDP) and/or pre-pregnancy hypertension (HTN) vs none of the three conditions
- Outcome
- Incident coronary heart disease (CHD) and all-cause mortality
- Follow-up
- Within 5 years of delivery and over the entire study period (up to 14 years)
Methodological detailspopulation-based, covariate-adjusted Cox proportional hazard models
- Population-based
- Covariate-adjusted Cox proportional hazard models
Main finding
As reported in the abstract
Incident CHD · within 5 years of delivery
Hazard ratio (95% CI)
Diabetesvs None of the three conditions
1.57(1.28–1.92)
HDPvs None of the three conditions
1.85(1.60–2.15)
HDP and diabetesvs None of the three conditions
2.29(1.73–3.03)
HDP and pre-pregnancy HTNvs None of the three conditions
3.13(2.66–3.68)
All three conditionsvs None of the three conditions
4.87(3.95–6.01)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortalityDiabetesvs None of the three conditionsCovariate-adjusted | 1.34 (1.01–1.78) | |
| All-cause mortalityHDP and pre-pregnancy HTNvs None of the three conditionsCovariate-adjusted | 1.53 (1.15–2.03) | |
| All-cause mortalityAll three conditionsvs None of the three conditionsCovariate-adjusted | 2.25 (1.51–3.36) | |
| 0.20.5125Hazard ratio (log scale) |
All-cause mortality
- Mortality risk not increased for HDP or HDP and diabetes
Original publication
Maternal coronary heart disease and mortality following hypertensive disorders of pregnancy and/or diabetes. Cardiovasc Diabetol. Published 11 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →