Gestational diabetes & diabetes in pregnancy
The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study
Authors' conclusion
This study contributes to the body of evidence that women with a history of certain pregnancy complications merit special attention in the prevention of cardiovascular disease. We recommend further exploration into these associations in larger cohorts.
Study context
- Population
- Women in the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort (2008–2021), cardiometabolic biomarkers 9 years postpartum
- Participants
- 35 / 55 / 19 / 186
- Exposure
- Pregnancy complications vs uncomplicated pregnancies
- Hypertensive disorders of pregnancy (HDP)n = 35
- Index pregnancy complicationn = 55
- Recurrent complicationn = 19
- Uncomplicatedn = 186reference
- Outcome
- Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (% higher)
- Follow-up
- 9 years postpartum
Methodological detailsadjusted linear regression
- Adjusted linear regression
Main finding
As reported in the abstract
% higher
23%
95% CI −4.4% to 57%
HDP
% higher
26%
95% CI 2.0%–55%
Index pregnancy complication
% higher
51%
95% CI 12%–104%
Recurrent complication
Observational data: associations, not effects.
Further findings
HbA1c, insulin, C-peptide and leptin · 9 years postpartum
- Elevations also seen with HbA1c, insulin, C-peptide and leptin, especially with recurrent complications
Original publication
The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study. J Clin Endocrinol Metab. Published 23 January 2025. doi:10.
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