Gestational diabetes & diabetes in pregnancy
Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes
Authors' conclusion
Results suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.
Study context
- Population
- Mother-child dyads; children aged 4–10 years, stratified by current body mass index (BMI) <85th or ≥85th percentile
- Participants
- 179 mother-child dyads
- Exposure
- Children by in utero exposure (maternal normal weight no gestational diabetes mellitus (GDM); overweight/obesity no GDM; overweight/obesity with GDM) and by current BMI <85th vs ≥85th percentile
- Outcome
- Leptin resistance (fasting leptin/fat mass index), adjusted for race, sex and Tanner stage
Main finding
As reported in the abstract
Leptin resistance in children
- Leptin resistance did not differ by in utero exposure
- BMI ≥85th percentile vs BMI <85th percentile: P < 0.001
- Two-way ANOVA adjusted for race, sex and Tanner stage
Observational data: associations, not effects.
Further findings
- Leptin resistance in women was associated with weight status and not prior GDM
Original publication
Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes. Pediatr Obes. Published 20 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →