Gestational diabetes & diabetes in pregnancy
Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers
Authors' conclusion
The results identify brain markers of prenatal GDM exposure and suggest that low cortical GMV may explain increased obesity risk for offspring prenatally exposed to GDM.
Study context
- Population
- Children aged 9–10 years and siblings across the US, baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study7% gestational diabetes mellitus (GDM)-exposed
- Participants
- 8,521 children
- Exposure
- Prenatal GDM exposure vs no exposure
- Outcome
- Brain structure (MRI) and its mediating role
Methodological detailssibling-discordance analysis, mediation analysis
- Sibling-discordance analysis
- Mediation analysis
Main finding
As reported in the abstract
- GDM exposure associated with lower global and regional cortical gray matter volume (GMV) in bilateral rostral middle frontal gyrus and superior temporal gyrus
- Global cortical GMV partially mediated associations between prenatal GDM exposure and child adiposity markers
Observational data: associations, not effects.
Further findings
- GDM-exposed siblings had lower global cortical GMV than unexposed siblings
- 28 sibling pairs discordant for GDM exposure
Original publication
Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers. Obesity (Silver Spring). Published 16 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →